Abstract No. 443 A proposed device for the prediction of a quantitative endpoint for transarterial embolization from real-time pressure measurements

We propose a device composed of catheter to deliver embolic agent as well pressure sensor monitor the extent occlusion. By continually measuring intravascular pressure, this allows for consistent, objective determination clinically relevant procedural endpoint; and prevention anterograde reflux off-target embolization. To assess functionality our prototype, we used vascular flow simulator, which included tree mesh filters that simulate beds, use in hepatic cancer site. The model received constant, pressure-controlled water at 100 mmHg gauge physiological blood. measure against volume particles injected, tris-acryl gelatin agents were injected increments 0.5 mL, providing an approximate 1-minute delay ensure stasis. Pressure changes measured real time directly adjacent catheter, using fiber optic integrated into prototype. quantify reduction through each injection stage, outflow rate. A stepwise increase was noted every mL until plateau reached. Once reached, repeated injections did not change pressure. An exponential relationship observed between beads. beads appeared linear plateaued 18 quadratic rate liquid vasculature found, indicated with coefficient 0.996 squared flow. logistic tip quantity system, demonstrating real-time measurements could be surrogate marker patient-specific vessel These findings correlative metric cessation during embolization procedures. near-complete stop indicates complete occlusion therefore, theory, end “on target” Thus, readings, physicians would know they had achieved 100% once over-embolization, associated nontarget embolization, avoided.